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Article

Computational detection of deleterious SNPs and their effect on sequence and structural level of the VHL gene.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2008

Rajasekaran R, Sudandiradoss C, George Priya Doss C, Singh Anshuman, Sethumadhavan Rao

Abstract excerpt

In this work we have analyzed the genetic variation that can alter the expression and the function of the VHL gene using computational methods. Of 110 single nucleotide polymorphisms (SNPs), 33 were found to be nonsynonymous (nsSNPs) and 23 SNPs were found in untranslated regions. Of the 33 nsSNPs investigated, 36.3% were found to be deleterious by both SIFT and PolyPhen servers. An untranslated region (UTR)...

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Identifiers

PMID: 18836774
DOI: 10.1007/s00335-008-9143-8

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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