Article
SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants.
Nucleic acids research - 1 Jan 2012
De Baets Greet, Van Durme Joost, Reumers Joke, Maurer-Stroh Sebastian, Vanhee Peter, Dopazo Joaquin, Schymkowitz Joost, Rousseau Frederic
Abstract excerpt
Single nucleotide variants (SNVs) are, together with copy number variation, the primary source of variation in the human genome and are associated with phenotypic variation such as altered response to drug treatment and susceptibility to disease. Linking structural effects of non-synonymous SNVs to functional outcomes is a major issue in structural bioinformatics. The SNPeffect database...
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