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Article

Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms.

PLoS computational biology - 25 Jul 2008

Cheng Tammy M K, Lu Yu-En, Vendruscolo Michele, Lio' Pietro, Blundell Tom L

Abstract excerpt

Recent analyses of human genome sequences have given rise to impressive advances in identifying non-synonymous single nucleotide polymorphisms (nsSNPs). By contrast, the annotation of nsSNPs and their links to diseases are progressing at a much slower pace. Many of the current approaches to analysing disease-associated nsSNPs use primarily sequence and evolutionary information, while structural information is...

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PMID: 18654622
DOI: 10.1371/journal.pcbi.1000135
PMCID: PMC2447880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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