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Article

An evaluation of different target enrichment methods in pooled sequencing designs for complex disease association studies.

PloS one - 1 Jan 2011

Day-Williams Aaron G, McLay Kirsten, Drury Eleanor, Edkins Sarah, Coffey Alison J, Palotie Aarno, Zeggini Eleftheria

Abstract excerpt

Pooled sequencing can be a cost-effective approach to disease variant discovery, but its applicability in association studies remains unclear. We compare sequence enrichment methods coupled to next-generation sequencing in non-indexed pools of 1, 2, 10, 20 and 50 individuals and assess their ability to discover variants and to estimate their allele frequencies. We find that pooled resequencing is most usefully...

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PMID: 22069447
DOI: 10.1371/journal.pone.0026279
PMCID: PMC3206031

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