Article
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment.
Blood - 4 Aug 2011
Alizadeh Ash A, Gentles Andrew J, Alencar Alvaro J, Liu Chih Long, Kohrt Holbrook E, Houot Roch, Goldstein Matthew J, Zhao Shuchun, Natkunam Yasodha, Advani Ranjana H, Gascoyne Randy D, Briones Javier, Tibshirani Robert J, Myklebust June H, Plevritis Sylvia K, Lossos Izidore S, Levy Ronald
Abstract excerpt
Several gene-expression signatures predict survival in diffuse large B-cell lymphoma (DLBCL), but the lack of practical methods for genome-scale analysis has limited translation to clinical practice. We built and validated a simple model using one gene expressed by tumor cells and another expressed by host immune cells, assessing added prognostic value to the clinical International Prognostic Index (IPI). LIM...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.