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Article

Rac mediates mouse spermatogonial stem cell homing to germline niches by regulating transmigration through the blood-testis barrier.

Cell stem cell - 4 Nov 2011

Takashima Seiji, Kanatsu-Shinohara Mito, Tanaka Takashi, Takehashi Masanori, Morimoto Hiroko, Shinohara Takashi

Abstract excerpt

The homing ability of spermatogonial stem cells (SSCs) allows them to migrate into niches after being transplantated into infertile testes. Transplanted SSCs attach to Sertoli cells and transmigrate through the blood-testis barrier (BTB), formed by inter-Sertoli tight junctions, toward niches on the basement membrane. The most critical step is the passage through the BTB, which limits the homing efficiency to...

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PMID: 22056142
DOI: 10.1016/j.stem.2011.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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