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Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease

14 Aug 2009

Abstract excerpt

BACKGROUND: The occurrence of duplications of the amyloid precursor protein gene (APP) has been described in European families with early-onset familial Alzheimer disease (EO-FAD) and cerebral amyloid angiopathy. However, the contribution of APP duplication to the development of AD in other ethnic populations remains undetermined. METHODS: The occurrence of APP duplication in probands from 25 families with FAD...

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PMID: 19684239
DOI: 10.1136/jnnp.2008.161703

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