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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

19 Aug 2006

Abstract excerpt

We assessed the impact of amyloid precursor protein (APP) gene locus duplications in early onset Alzheimer's disease in a Dutch population-based sample. Using real-time PCR and an in-house-developed multiplex amplicon quantification assay, we identified a genomic APP duplication in 1 out of 10 multigenerational families segregating early onset Alzheimer's disease. In this family, cerebral amyloid angiopathy (CAA)...

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PMID: 16921174
DOI: 10.1093/brain/awl203

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