Article
Prophylaxis for severe hemophilia: experience from Europe and the United States.
Seminars in thrombosis and hemostasis - 1 Feb 2003
van den Berg H Marijke, Fischer Kathelijn
Abstract excerpt
Since the late 1950s, prophylactic therapy has been used in patients with severe hemophilia in order to convert their phenotype into the phenotype of moderate hemophilia. In the early years, prophylaxis was mostly started after the development of arthropathy. This secondary prophylaxis decreased the number of bleeds but did not halt the development of arthropathy. With the start of primary prophylaxis, however,...
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