Article
Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2012
Eisenhofer Graeme, Lenders Jacques W M, Siegert Gabriele, Bornstein Stefan R, Friberg Peter, Milosevic Dragana, Mannelli Massimo, Linehan W Marston, Adams Karen, Timmers Henri J, Pacak Karel
Abstract excerpt
BACKGROUND: There are currently no reliable biomarkers for malignant pheochromocytomas and paragangliomas (PPGLs). This study examined whether measurements of catecholamines and their metabolites might offer utility for this purpose. METHODS: Subjects included 365 patients with PPGLs, including 105 with metastases, and a reference population of 846 without the tumour. Eighteen catecholamine-related analytes were...
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