Article
Head/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine.
Endocrine-related cancer - 21 Mar 2022
Richter Susan, Qiu Bei, Ghering Mirthe, Kunath Carola, Constantinescu Georgiana, Luths Charlotte, Pamporaki Christina, Bechmann Nicole, Meuter Leah, Kwapiszewska Aleksandra, Deutschbein Timo, Nölting Svenja, Peitzsch Mirko, Robledo Mercedes, Prejbisz Aleksander, Pacak Karel, Gudziol Volker, Timmers Henri J L M, Eisenhofer Graeme
Abstract excerpt
Head and neck paragangliomas (HNPGLs) are tumors of parasympathetic origin that occur at variable locations and are often secondary to germline mutations in succinate dehydrogenase (SDH) subunit genes. Occasionally, these tumors produce catecholamines. Here, we assessed whether different locations of HNPGLs relate to the presence of SDHx mutations, catecholamine production and other presentations. In this...
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