Article
The modifying effect of Xmn1-HBG2 on thalassemic phenotype is associated with its linked elements in the beta globin locus control region, including the palindromic site at 5'HS4.
Blood cells, molecules & diseases - 15 Jan 2012
Neishabury Maryam, Zamani Shahbaz, Azarkeivan Azita, Abedini Seyedeh Sedigheh, Darvish Hossein, Zamani Fahimeh, Najmabadi Hossein
Abstract excerpt
The core sequence of 5'HS4-beta globin locus control region and Xmn1-HBG2 site were analyzed and compared among 86 thalassemia patients with homozygous or compound heterozygous beta globin gene mutations and 101 normal individuals. Frequency of the G allele in the polymorphic palindromic sequence of 5'HS4 (TGGGG A/G CCCCA) and positive Xmn1-HBG2 profile was significantly higher in thalassemia patients compared to...
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