Electromobility Shift Assay Reveals Evidence in Favor of Allele-Specific Binding of RUNX1 to the 5' Hypersensitive Site 4-Locus Control Region.

doi:10.1080/03630269.2016.1189931

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Article

Electromobility Shift Assay Reveals Evidence in Favor of Allele-Specific Binding of RUNX1 to the 5' Hypersensitive Site 4-Locus Control Region.

Hemoglobin - 1 Aug 2016

Dehghani Hossein, Ghobakhloo Sepideh, Neishabury Maryam

Abstract excerpt

In our previous studies on the Iranian β-thalassemia (β-thal) patients, we identified an association between the severity of the β-thal phenotype and the polymorphic palindromic site at the 5' hypersensitive site 4-locus control region (5'HS4-LCR) of the β-globin gene cluster. Furthermore, a linkage disequilibrium was observed between this region and XmnI-HBG2 in the patient population. Based on this data, it was...

Topics

Alleles
Binding Sites
Core Binding Factor Alpha 2 Subunit
Electrophoretic Mobility Shift Assay
Humans
Inverted Repeat Sequences
Locus Control Region
Phenotype
Protein Binding

Source

Open in PubMed

Identifiers

PMID: 27492765
DOI: 10.1080/03630269.2016.1189931

Genes

RUNX1
HBG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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