Emergent 2009 influenza A(H1N1) viruses containing HA D222N mutation associated with severe clinical outcomes in the Americas.

doi:10.1016/j.jcv.2011.09.004

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Article

Emergent 2009 influenza A(H1N1) viruses containing HA D222N mutation associated with severe clinical outcomes in the Americas.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jan 2012

Houng Huo-Shu H, Garner Jason, Zhou Yanfei, Lyons Arthur, Kuschner Robert, Deye Gregory, St Clair Kristina, Douce Richard W, Chicaiza Wilson, Blair Patrick J, Myers Christopher A, Burke Ronald L, Sanchez Jose L, Williams Maya, Halsey Eric S

Abstract excerpt

BACKGROUND: During the 2010-2011 influenza season, a small sub-group of 2009 influenza A(H1N1) viruses (hereafter referred to as 2009 A(H1N1)) emerged that was associated with more severe clinical outcomes in Ecuador and North America. Genetically, the haemagglutinin (HA) of this sub-clade was distinct from HAs found in viruses associated with severe outbreaks in 2010 from the United Kingdom and from other global...

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PMID: 22036040
DOI: 10.1016/j.jcv.2011.09.004

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