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Article

Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers.

Hepatology (Baltimore, Md.) - 1 Mar 2012

Russo Lucia, Gracia-Sancho Jorge, García-Calderó Héctor, Marrone Giusi, García-Pagán Juan Carlos, García-Cardeña Guillermo, Bosch Jaime

Abstract excerpt

UNLABELLED: Pathophysiological alterations in the endothelial phenotype result in endothelial dysfunction. Flow cessation, occurring during organ procurement for transplantation, triggers the endothelial dysfunction characteristic of ischemia/reperfusion injury, partly due to a reduction in the expression of the vasoprotective transcription factor Kruppel-like Factor 2 (KLF2). We aimed at (1) characterizing the...

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PMID: 22031447
DOI: 10.1002/hep.24755

Genes

KLF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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