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Article

Natural resistance to liver cold ischemia-reperfusion injury associated with the hibernation phenotype.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2005

Lindell Susanne L, Klahn Shawna L, Piazza Timothy M, Mangino Martin J, Torrealba Jose R, Southard James H, Carey Hannah V

Abstract excerpt

The success of liver grafts is currently limited by the length of time organs are cold preserved before transplant. Novel insights to improve viability of cold-stored organs may emerge from studies with animals that naturally experience low body temperatures (T(b)) for extended periods. In this study, we tested whether livers from hibernating ground squirrels tolerate cold ischemia-warm reperfusion (cold I/R) for...

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Identifiers

PMID: 15701622
DOI: 10.1152/ajpgi.00223.2004

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