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Article

Octapeptide repeat insertions in the prion protein gene and early onset dementia.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 2004

Croes E A, Theuns J, Houwing-Duistermaat J J, Dermaut B, Sleegers K, Roks G, Van den Broeck M, van Harten B, van Swieten J C, Cruts M, Van Broeckhoven C, van Duijn C M

Abstract excerpt

OBJECTIVES: The most common familial early onset dementia mutations are found in the genes involved in Alzheimer's disease; the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and 2) genes; the prion protein gene (PRNP) may be involved. METHODS: Following identification of a two-octapeptide repeat insertion in PRNP, we conducted a meta-analysis to investigate the relation of number of PRNP...

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Source

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Identifiers

PMID: 15258222
DOI: 10.1136/jnnp.2003.020198
PMCID: PMC1739180

Genes

PRNP
APP
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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