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NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation

18 Sept 2013

Abstract excerpt

Maternal-effect mutations in NLRP7 cause rare biparentally inherited hydatidiform moles (BiHMs), abnormal pregnancies containing hypertrophic vesicular trophoblast but no embryo. BiHM trophoblasts display abnormal DNA methylation patterns affecting maternally methylated germline differentially methylated regions (gDMRs), suggesting that NLRP7 plays an important role in reprogramming imprinted gDMRs. How NLRP7-a...

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Share to Epigenetics and DNA Methylation
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PMID: 24105472
DOI: 10.1093/hmg/ddt457

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