Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.

doi:10.1128/AAC.05394-11

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Article

Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.

Antimicrobial agents and chemotherapy - 1 Jan 2012

Tashiro Masato, Izumikawa Koichi, Minematsu Asuka, Hirano Katsuji, Iwanaga Naoki, Ide Shotaro, Mihara Tomo, Hosogaya Naoki, Takazono Takahiro, Morinaga Yoshitomo, Nakamura Shigeki, Kurihara Shintaro, Imamura Yoshifumi, Miyazaki Taiga, Nishino Tomoya, Tsukamoto Misuzu, Kakeya Hiroshi, Yamamoto Yoshihiro, Yanagihara Katsunori, Yasuoka Akira, Tashiro Takayoshi, Kohno Shigeru

Abstract excerpt

We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates...

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PMID: 22024829
DOI: 10.1128/AAC.05394-11
PMCID: PMC3256053

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