Article
Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C.
Antiviral therapy - 1 Jan 2011
Umemura Takeji, Joshita Satoru, Yoneda Suguru, Katsuyama Yoshihiko, Ichijo Tetsuya, Matsumoto Akihiro, Yoshizawa Kaname, Ota Masao, Tanaka Eiji
Abstract excerpt
BACKGROUND: Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection. METHODS: To clarify their association and predictive value in treatment outcome of genotype 1 HCV-infected patients, we measured pretreatment serum IL-10, IL-12p40 and IL-18 levels using multiplex...
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