Low IL10 serum levels as key factor for predicting the sustained virological response to IFNα/ribavirin in Brazilian patients with HCV carrying IL28B CT/TT genotype.

doi:10.1016/j.humimm.2014.06.017

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Article

Low IL10 serum levels as key factor for predicting the sustained virological response to IFNα/ribavirin in Brazilian patients with HCV carrying IL28B CT/TT genotype.

Human immunology - 1 Aug 2014

Vasconcelos Luydson Richardson Silva, Moura Patricia, do Carmo Rodrigo Feliciano, Pereira Luciano Beltrão, Cavalcanti Maria do Socorro de Mendonça, Aroucha Dayse Celia Barbosa Lins, Dutra Rosa Amália, Pereira Leila Maria Moreira Beltrão

Abstract excerpt

PROPOSE: IL28B polymorphisms rs12979860 CC genotype was associated to protection of HCV infection and sustained virological response (SVR) in HCV infected patients treated with pegIFNα/ribavirin (IFNα/RIB), however, this polymorphism frequency varies depending on genetic components. Studies with larger number of Brazilian individuals, determining IL28B polymorphisms is lacking. Regarding to treatment response,...

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PMID: 24994464
DOI: 10.1016/j.humimm.2014.06.017

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