Article
Molecular profile of drug resistance in tuberculous meningitis from southwest china.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Dec 2011
Duo Lina, Ying Binwu, Song Xingbo, Lu Xiaojun, Ye Yuanxin, Fan Hong, Xin Junping, Wang Lanlan
Abstract excerpt
BACKGROUND: Tuberculous meningitis (TBM) is the most severe form of extrapulmonary tuberculosis and causes high mortality and morbidity. Isoniazid resistance is strongly predictive of death in patients with TBM. METHODS: In the present study, using polymerase chain reaction (PCR) and Genotype MTBDRplus line-probe assay, we investigated the drug resistance in patients with TBM living in Southwest China. RESULTS:...
Topics
- Adolescent
- Adult
- Aged
- Antitubercular Agents
- Cerebrospinal Fluid
- China
- Drug Resistance, Bacterial
- Female
- Genotype
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Mycobacterium tuberculosis