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Article

Feeding history and obese-prone genotype increase survival of rats exposed to a challenge of food restriction and wheel running.

Obesity (Silver Spring, Md.) - 1 Sept 2012

Diane Abdoulaye, Pierce W David, Heth C Donald, Russell James C, Richard Denis, Proctor Spencer D

Abstract excerpt

We hypothesized that obese-prone genotype and history of food restriction confer a survival advantage to genetically obese animals under environmental challenge. Male juvenile JCR:LA-cp rats, obese-prone and lean-prone, were exposed to 1.5 h daily meals and 22.5-h voluntary wheel running, a procedure inducing activity anorexia (AA). One week before the AA challenge, obese-prone rats were freely fed (obese-FF), or...

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PMID: 22016097
DOI: 10.1038/oby.2011.326

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