Article
IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.
The Journal of infectious diseases - 15 Dec 2011
Shebl Fatma M, Pfeiffer Ruth M, Buckett Dianna, Muchmore Brian, Chen Sabrina, Dotrang Myhanh, Prokunina-Olsson Ludmila, Edlin Brian R, O'Brien Thomas R
Abstract excerpt
Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance. For rs12979860, adjusted odds ratios for spontaneous HCV clearance were as follows: IL28B-CC, 3.88 (P < .001); IL28B-CT, 1.48 (P = .08). On the basis of Akaike information criteria values and χ(2) tests, a supra-additive (quadratic) model...
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