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Article

Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes.

Cancer research - 1 Dec 2011

Ha Ngoc-Han, Nair Vasudha S, Reddy Divijendra Natha Sirigiri, Mudvari Prakriti, Ohshiro Kazufumi, Ghanta Krishna Sumanth, Pakala Suresh B, Li Da-Qiang, Costa Luis, Lipton Allan, Badwe Rajendra A, Fuqua Suzanne, Wallon Margaretha, Prendergast George C, Kumar Rakesh

Abstract excerpt

Triple-negative breast cancer (TNBC) is characterized by the lack of expression of estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2). However, pathways responsible for downregulation of therapeutic receptors, as well as subsequent aggressiveness, remain unknown. In this study, we discovered that lactoferrin (Lf) efficiently downregulates levels of ER-α,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22006997
DOI: 10.1158/0008-5472.CAN-11-1143
PMCID: PMC3617573

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