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Article

High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.

Cancer - 1 Jun 2012

Choy Edwin, Hornicek Francis, MacConaill Laura, Harmon David, Tariq Zeeshan, Garraway Levi, Duan Zhenfeng

Abstract excerpt

BACKGROUND: The identification of new genes that are mutated in osteosarcomas is critical to developing a better understanding of the molecular pathogenesis of this disease and discovering new targets for therapeutic development. METHODS: The authors identified somatic nonsynonymous coding mutations in oncogenes associated with human cancers and hotspot mutations from tumor suppressor genes that were either well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22006429
DOI: 10.1002/cncr.26617
PMCID: PMC3272156

Genes

CABYR
CDH1
CTNNB1
CUBN
FSCB
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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