Article
Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus.
Investigative ophthalmology & visual science - 31 Oct 2011
Burdon Kathryn P, Macgregor Stuart, Bykhovskaya Yelena, Javadiyan Sharhbanou, Li Xiaohui, Laurie Kate J, Muszynska Dorota, Lindsay Richard, Lechner Judith, Haritunians Talin, Henders Anjali K, Dash Durga, Siscovick David, Anand Seema, Aldave Anthony, Coster Douglas J, Szczotka-Flynn Loretta, Mills Richard A, Iyengar Sudha K, Taylor Kent D, Phillips Tony, Montgomery Grant W, Rotter Jerome I, Hewitt Alex W, Sharma Shiwani, Rabinowitz Yaron S, Willoughby Colin, Craig Jamie E
Abstract excerpt
PURPOSE: Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS: Two genome-wide association scans were undertaken in parallel. The first used pooled DNA from an Australian cohort,...
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