Article
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma.
Gastroenterology - 1 May 2011
Villanueva Augusto, Hoshida Yujin, Battiston Carlo, Tovar Victoria, Sia Daniela, Alsinet Clara, Cornella Helena, Liberzon Arthur, Kobayashi Masahiro, Kumada Hiromitsu, Thung Swan N, Bruix Jordi, Newell Philippa, April Craig, Fan Jian-Bing, Roayaie Sasan, Mazzaferro Vincenzo, Schwartz Myron E, Llovet Josep M
Abstract excerpt
BACKGROUND & AIMS: In approximately 70% of patients with hepatocellular carcinoma (HCC) treated by resection or ablation, disease recurs within 5 years. Although gene expression signatures have been associated with outcome, there is no method to predict recurrence based on combined clinical, pathology, and genomic data (from tumor and cirrhotic tissue). We evaluated gene expression signatures associated with...
Topics
- Biomarkers, Tumor
- Carcinoma, Hepatocellular
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genotype
- Hepatectomy
- Humans
- Incidence