Article
Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration.
PloS one - 1 Jan 2011
Muto Jun, Naidu Nandita Natasha, Yamasaki Kenshi, Pineau Nathalie, Breton Lionel, Gallo Richard L
Abstract excerpt
As C-Xyloside has been suggested to be an initiator of glycosaminoglycan (GAG) synthesis, and GAGs such as Dermatan sulfate (DS) are potent enhancers of fibroblast growth factor (FGF)--10 action, we investigated if a C-Xylopyranoside derivative, (C-β-D-xylopyranoside-2-hydroxy-propane, C-Xyloside), could promote DS production by cultured normal human keratinocytes, how this occurs and if C-Xyloside could also...
Topics
- Animals
- CHO Cells
- Cell Movement
- Cell Proliferation
- Cricetinae
- Cricetulus
- Culture Media, Conditioned
- Dermatan Sulfate
- Fibroblast Growth Factor 10
- Glycosides
- Humans