Article
Glutathione S-transferase gene polymorphisms in neonatal hyperbilirubinemia.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Jan 2012
Abdel Ghany Eman Abdel Ghany, Hussain Nouran Fahmy, Botros Shahira Kamal Anis
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are a polymorphic superfamily of multifunctional enzymes known to play an important role in the detoxification of several substances. GSTM1 and GSTT1 are present in the liver in relatively high levels. Polymorphisms of the GSTM1 and GSTT1 genes may affect ligandin functions that are important in bilirubin transportation. OBJECTIVE: The aim of this study was to...
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