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Oxidative Stress and Necrotizing Enterocolitis in Preterm Newborns: The Role of GSTM1 and GSTT1 Null Genotypes.

Biomolecules - 18 Jun 2026

Duarte Alexandre Alberto Barros, Ferdinando Danielle Lopes Teixeira, Piatto Vânia Belintani, Caldas Heloísa Cristina

Abstract excerpt

Necrotizing enterocolitis (NEC) is a multifactorial disease associated with prematurity, intestinal hypoperfusion, dysbiosis, and oxidative stress. Interindividual variability in disease occurrence suggests a role for genetic susceptibility. Null genotypes of the GSTM1 and GSTT1 genes result in absent glutathione S-transferase activity and may impair antioxidant defenses. This study investigated whether GSTM1 and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 42352369
DOI: 10.3390/biom16060900
PMCID: PMC13297310

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships.

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