Ki-ras oncogene mutations in non-HPV-associated anal carcinoma.

doi:10.1002/path.1711610203

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Article

Ki-ras oncogene mutations in non-HPV-associated anal carcinoma.

The Journal of pathology - 1 Jun 1990

Hiorns L R, Scholefield J H, Palmer J G, Shepherd N A, Kerr I B

Abstract excerpt

Human papillomavirus 16 (HPV 16) DNA is found in a high proportion of anal squamous cell carcinomas in whose genesis it is thought to play an important role. In addition, it can be shown to cooperate in vitro with activated ras oncogenes in cellular transformation. We have therefore screened a se...

Topics

Anus Neoplasms
Carcinoma, Squamous Cell
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Mutation

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