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Article

Effects of APRIL (TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL.

Modern rheumatology - 1 Aug 2012

Furuya Takumi, Koga Minori, Hikami Koki, Kawasaki Aya, Tsuchiya Naoyuki

Abstract excerpt

Functional APRIL (TNFSF13) is a secreted trimer generated by furin protease cleavage. We previously reported the association of APRIL haplotypes formed by two nonsynonymous polymorphisms, Gly67Arg and Asn96Ser, with systemic lupus erythematosus. Here, we tested the hypothesis that polymorphisms and/or alternative splicing may influence the generation of soluble APRIL (sAPRIL). HEK 293T cells were transfected with...

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Source

Identifiers

PMID: 21984075
DOI: 10.1007/s10165-011-0539-z

Genes

TNFSF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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