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Article

Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact

7 May 2019

Abstract excerpt

BACKGROUND: miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic miR-340-5p is a tumor suppressor miRNA epigenetically silenced by promoter DNA methylation of its host gene in multiple myeloma. RESULTS: By pyrosequencing-confirmed methylation-specific PCR,...

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PMID: 31064412
DOI: 10.1186/s13148-019-0669-2

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