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Article

Retromer regulates apical-basal polarity through recycling Crumbs.

Developmental biology - 1 Dec 2011

Zhou Bo, Wu Yihui, Lin Xinhua

Abstract excerpt

Epithelial cells are characterized by an "apical-basal" polarization. The transmembrane protein Crumbs (Crb) is an essential apical determinant which confers apical membrane identity. Previous studies indicated that Crb did not constantly reside on the apical membrane, but was actively recycled. However, the cellular mechanism(s) underlying this process was unclear. Here we showed that in Drosophila, retromer,...

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Identifiers

PMID: 21958744
DOI: 10.1016/j.ydbio.2011.09.009

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