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Article

Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2012

Yuan Hongyan, Upadhyay Geeta, Yin Yuzhi, Kopelovich Levy, Glazer Robert I

Abstract excerpt

Stem cell antigen-1 (Sca-1, Ly6A) is a glycerophosphatidylinositol (GPI)-anchored protein that was identified as a murine marker of bone marrow stem cells. Although Sca-1 is widely used to enrich for stem and progenitor cells in various tissues, little is known about its function and associated signaling pathways in normal and malignant cells. Here, we report that the absence of Sca-1 in the mammary gland...

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Identifiers

PMID: 21955520
DOI: 10.1158/1940-6207.CAPR-11-0256
PMCID: PMC3252486

Genes

GPI
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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