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Article

Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats.

Cardiovascular research - 1 Dec 2011

Taniguchi Yayoi, Takahashi Naohiko, Fukui Akira, Nagano-Torigoe Yasuko, Thuc Luong Cong, Teshima Yasushi, Shinohara Tetsuji, Wakisaka Osamu, Ooie Tatsuhiko, Murozono Yukichi, Yufu Kunio, Nakagawa Mikiko, Hara Masahide, Yoshimatsu Hironobu, Saikawa Tetsunori

Abstract excerpt

AIMS: We tested the hypothesis that candesartan, an angiotensin II (AII) type 1 receptor antagonist, would restore the depressed phosphatidylinositol 3 (PI3) kinase-dependent Akt phosphorylation, an essential signal to induce heat-shock protein 72 (Hsp72) in response to hyperthermia, in Otsuka Long-Evans Tokushima fatty (OLETF) rats. METHODS AND RESULTS: At 14 weeks of age, male OLETF rats and Long-Evans...

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Identifiers

PMID: 21952935
DOI: 10.1093/cvr/cvr254

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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