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Article

Human dendritic cells transfected with amplified MUC1 mRNA stimulate cytotoxic T lymphocyte responses against pancreatic cancer in vitro.

Journal of gastroenterology and hepatology - 1 Oct 2011

Chen Jiang, Li Hong-Yu, Wang Di, Zhao Jia-Jun, Guo Xiao-Zhong

Abstract excerpt

BACKGROUND AND AIM: Mucin (MUC) 1 is an epithelial cell glycoprotein that is aberrantly overexpressed in many adenocarcinomas, including pancreatic cancer (PC), providing an ideal tumor-associated antigen and target for immunotherapy. In this study, we investigated whether the cytotoxic T lymphocytes (CTLs) induced by dendritic cells (DCs) transfected with amplified MUC1 mRNA could respond against PC in vitro....

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Source

Identifiers

PMID: 21950745
DOI: 10.1111/j.1440-1746.2011.06778.x

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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