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Article

Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones.

PloS one - 1 Jan 2011

Korvald Hanne, Mølstad Moe Anne Margrethe, Cederkvist F Henning, Thiede Bernd, Laerdahl Jon K, Bjørås Magnar, Alseth Ingrun

Abstract excerpt

2-Oxoglutarate (2OG) dependent dioxygenases are ubiquitous iron containing enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. They participate in a wide range of biological processes including collagen biosynthesis, fatty acid metabolism, hypoxic sensing and demethylation of nucleic acids and histones. Although substantial progress has been made in elucidating their...

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Identifiers

PMID: 21949882
DOI: 10.1371/journal.pone.0025188
PMCID: PMC3175000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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