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Article

Using networks to measure similarity between genes: association index selection.

Nature methods - 1 Dec 2013

Fuxman Bass Juan I, Diallo Alos, Nelson Justin, Soto Juan M, Myers Chad L, Walhout Albertha J M

Abstract excerpt

Biological networks can be used to functionally annotate genes on the basis of interaction-profile similarities. Metrics known as association indices can be used to quantify interaction-profile similarity. We provide an overview of commonly used association indices, including the Jaccard index and the Pearson correlation coefficient, and compare their performance in different types of analyses of biological...

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PMID: 24296474
DOI: 10.1038/nmeth.2728
PMCID: PMC3959882

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