Article
Performance comparison of exome DNA sequencing technologies.
Nature biotechnology - 25 Sept 2011
Clark Michael J, Chen Rui, Lam Hugo Y K, Karczewski Konrad J, Chen Rong, Euskirchen Ghia, Butte Atul J, Snyder Michael
Abstract excerpt
Whole exome sequencing by high-throughput sequencing of target-enriched genomic DNA (exome-seq) has become common in basic and translational research as a means of interrogating the interpretable part of the human genome at relatively low cost. We present a comparison of three major commercial exome sequencing platforms from Agilent, Illumina and Nimblegen applied to the same human blood sample. Our results...
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