Article
High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia.
Journal of human genetics - 1 Dec 2011
Nakayama Kazuhiro, Yanagisawa Yoshiko, Ogawa Ayumi, Ishizuka Yuumi, Munkhtulga Lkhagvasuren, Charupoonphol Phitaya, Supannnatas Somjit, Kuartei Stevenson, Chimedregzen Ulziiburen, Koda Yoshiro, Ishida Takafumi, Kagawa Yasuo, Iwamoto Sadahiko
Abstract excerpt
MLXIPL is a transcription factor integral to the regulation of glycolysis and lipogenesis in the liver. Common variants of the MLXIPL gene (MLXIPL) are known to influence plasma triglyceride levels in people of European descent. As MLXIPL has a key role in energy storage, genetic variations of the MLXIPL may be relevant to physiological adaptations to nutritional stresses that have occurred during the evolution...
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