Article
Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.
PLoS pathogens - 1 Sept 2011
Korotkov Konstantin V, Johnson Tanya L, Jobling Michael G, Pruneda Jonathan, Pardon Els, Héroux Annie, Turley Stewart, Steyaert Jan, Holmes Randall K, Sandkvist Maria, Hol Wim G J
Abstract excerpt
Type II secretion systems (T2SSs) are critical for secretion of many proteins from Gram-negative bacteria. In the T2SS, the outer membrane secretin GspD forms a multimeric pore for translocation of secreted proteins. GspD and the inner membrane protein GspC interact with each other via periplasmic domains. Three different crystal structures of the homology region domain of GspC (GspC(HR)) in complex with either...
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