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Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis

14 May 2021

Abstract excerpt

Mycobacterium tuberculosis (Mtb) has complex and dynamic interactions with the human host, and subpopulations of Mtb that emerge during infection can influence disease outcomes. This study implicates zinc ion (Zn2+) availability as a likely driver of bacterial phenotypic heterogeneity in vivo. Zn2+ sequestration is part of "nutritional immunity", where the immune system limits micronutrients to control pathogen...

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PMID: 33989345
DOI: 10.1371/journal.ppat.1009570

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