Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hardy-Weinberg disequilibrium of the IL-18 C-607A SNP suggesting selective advantage of heterozygotes.

Biochemical genetics - 1 Feb 2012

Chen Chuan Fei, Gan Yik Yuen

Abstract excerpt

Interleukin-18 (IL-18) plays a key role in autoimmune, inflammatory, and infectious diseases. The IL-18 gene contains a C to A single nucleotide polymorphism (SNP) at position -607 (C-607A) within the promoter region, which was found to affect the promoter activity and subsequently the protein level of IL-18. We investigated this SNP in a group of healthy Singaporeans and found that CA was the most common...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Ethnicity
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-18

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Share to Singapore

Source

Identifiers

PMID: 21922295
DOI: 10.1007/s10528-011-9459-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hardy-Weinberg disequilibrium of the IL-18 C-607A SNP suggesting selective advantage of heterozygotes.PMID 21922295Read ↗

Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors.Semantic proximity Read ↗

Interleukin-18 promoter gene polymorphisms in Chinese patients with systemic lupus erythematosus: association with CC genotype at position -607.Semantic proximity Read ↗

Interleukin 18 -607 A/C Gene Polymorphism is Associated With Susceptibility to IgA Nephropathy in a Chinese Han Population.Semantic proximity Read ↗

Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.Semantic proximity Read ↗

Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their association with oral squamous cell carcinoma (OSCC) in northern India.Semantic proximity Read ↗

The -607C/A polymorphisms in interleukin-18 gene promoter contributes to cancer risk: evidence from a meta-analysis of 22 case-control studies.Semantic proximity Read ↗

Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population.Semantic proximity Read ↗

Interleukin-18 gene polymorphisms in systemic lupus erythematosus: relation to disease status.Semantic proximity Read ↗

Association of interleukin-18 gene polymorphism (-607A/A genotype) with susceptibility to chronic hepatitis B virus infection.Semantic proximity Read ↗

Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

The Protective Role of Haplotype -607A/-137C in the Promoter Region of IL-18 Gene and HBV Infection Risk in the North Indian Population.Semantic proximity Read ↗

A meta-analysis evaluating the relationship between IL-18 gene promoter polymorphisms and an individual's susceptibility to HCV infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.