Article
Transgenerational epigenetic instability is a source of novel methylation variants.
Science (New York, N.Y.) - 21 Oct 2011
Schmitz Robert J, Schultz Matthew D, Lewsey Mathew G, O'Malley Ronan C, Urich Mark A, Libiger Ondrej, Schork Nicholas J, Ecker Joseph R
Abstract excerpt
Epigenetic information, which may affect an organism's phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce meiotically stable epialleles that affect transcription and morphology, but the rates of spontaneous gain or loss of DNA methylation are unknown. We examined spontaneously occurring variation in DNA methylation in Arabidopsis thaliana...
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