Establishing epigenetic variation during genome reprogramming.

doi:10.4161/rna.24085

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Article

Establishing epigenetic variation during genome reprogramming.

RNA biology - 1 Apr 2013

Borges Filipe, Martienssen Robert A

Abstract excerpt

Transgenerational reprogramming of DNA methylation is important for transposon silencing and epigenetic inheritance. A stochastic regulation of methylation states in the germline may lead to epigenetic variation and the formation of epialleles that contribute to phenotypic variation. In Arabidopsis thaliana inbred lines, the frequency of single base variation of DNA methylation is much higher than genetic...

Topics

Alleles
Arabidopsis
DNA Glycosylases
DNA Methylation
DNA Transposable Elements
Epigenesis, Genetic
Genetic Variation
Genome, Plant
Germ Cells, Plant
Pollen
RNA Interference
RNA, Small Interfering

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PMID: 23774895
DOI: 10.4161/rna.24085
PMCID: PMC3710355

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