Article
Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families.
Genome biology - 14 Sept 2011
Brownstein Zippora, Friedman Lilach M, Shahin Hashem, Oron-Karni Varda, Kol Nitzan, Abu Rayyan Amal, Parzefall Thomas, Lev Dorit, Shalev Stavit, Frydman Moshe, Davidov Bella, Shohat Mordechai, Rahile Michele, Lieberman Sari, Levy-Lahad Ephrat, Lee Ming K, Shomron Noam, King Mary-Claire, Walsh Tom, Kanaan Moien, Avraham Karen B
Abstract excerpt
BACKGROUND: Identification of genes responsible for medically important traits is a major challenge in human genetics. Due to the genetic heterogeneity of hearing loss, targeted DNA capture and massively parallel sequencing are ideal tools to address this challenge. Our subjects for genome analysis are Israeli Jewish and Palestinian Arab families with hearing loss that varies in mode of inheritance and severity....
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