Article
A next-generation sequencing gene panel (MiamiOtoGenes) for comprehensive analysis of deafness genes.
Hearing research - 1 Mar 2016
Tekin Demet, Yan Denise, Bademci Guney, Feng Yong, Guo Shengru, Foster Joseph, Blanton Susan, Tekin Mustafa, Liu Xuezhong
Abstract excerpt
Extreme genetic heterogeneity along with remarkable variation in the distribution of causative variants across in different ethnicities makes single gene testing inefficient for hearing loss. We developed a custom capture/next-generation sequencing gene panel of 146 known deafness genes with a total target size of approximately 1 MB. The genes were identified by searching databases including Hereditary Hearing...
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