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Africa: the next frontier for human disease gene discovery?

Human molecular genetics - 15 Oct 2011

Ramsay Michèle, Tiemessen Caroline T, Choudhury Ananyo, Soodyall Himla

Abstract excerpt

The populations of Africa harbour the greatest human genetic diversity following an evolutionary history tracing its beginnings on the continent to time before the emergence of Homo sapiens. Signatures of selection are detectable as responses to ancient environments and cultural practices, modulated by more recent events including infectious epidemics, migrations, admixture and, of course, chance. The age of...

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PMID: 21908518
DOI: 10.1093/hmg/ddr401

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